The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway. Gli3 contains a repressor domain in its N-terminus from residue G106 to E236. In this study we have characterized the intracellular structure of the Gli3 repressor domain using a combined bioinformatics and experimental approach. https://www.adventuresonabike.com/product-category/sleeveless/
The transcriptional repressor domain of Gli3 is intrinsically disordered.
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