Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit. generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection. activating nucleases that degrade the nucleic acid of both invader and host. This can lead to dormancy or cell death; to avoid this. https://www.marcelovicente.com/product-category/curl-definer-treatment/